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Poppenberger, B; Rozhon, W; Khan, M; Husar, S; Adam, G; Luschnig, C; Fujioka, S; Sieberer, T.
(2011): CESTA, a positive regulator of brassinosteroid biosynthesis
EMBO J. 2011; 30(6): 1149-1161. FullText FullText_BOKU

Abstract:: Brassinosteroids (BRs) are steroid hormones that are essential for the development of plants. A tight control of BR homeostasis is vital for modulating their impact on growth responses. Although it is recognized that the rapid adaptation of de novo synthesis has a key role in adjusting required BR levels, our knowledge of the mechanisms governing feedback control is limited. In this study, we identify the transcription factor CESTA as a regulator of BR biosynthesis. ces-D was isolated in a screen of Arabidopsis mutants by BR over-accumulation phenotypes. Loss-of-function analysis and the use of a dominant repressor version revealed functional overlap among CESTA and its homologues and confirmed the role of CESTA in the positive control of BR-biosynthetic gene expression. We provide evidence that CESTA interacts with its homologue BEE1 and can directly bind to a G-box motif in the promoter of the BR biosynthesis gene CPD. Moreover, we show that CESTA subnuclear localization is BR regulated and discuss a model, in which CESTA interplays with BEE1 to control BR biosynthesis and other BR responses. The EMBO Journal (2011) 30, 1149-1161. doi:10.1038/emboj.2011.35; Published online 18 February 2011
Authors BOKU Wien:: Adam Gerhard; Luschnig Christian
Find related publications in this database (Keywords): brassinosteroids; homeostasis; signalling; steroid; transcription factor