University of Natural Resources and Life Sciences, Vienna (BOKU) - Research portal
Selected Publication:
Kuhbier, JW; Weyand, B; Radtke, C; Vogt, PM; Kasper, C; Reimers, K.
(2010):
Isolation, characterization, differentiation, and application of adipose-derived stem cells.
Adv Biochem Eng Biotechnol. 2010; 123(3):55-105
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- Abstract:
- While bone marrow-derived mesenchymal stem cells are known and have been investigated for a long time, mesenchymal stem cells derived from the adipose tissue were identified as such by Zuk et al. in 2001. However, as subcutaneous fat tissue is a rich source which is much more easily accessible than bone marrow and thus can be reached by less invasive procedures, adipose-derived stem cells have moved into the research spotlight over the last 8 years. Isolation of stromal cell fractions involves centrifugation, digestion, and filtration, resulting in an adherent cell population containing mesenchymal stem cells; these can be subdivided by cell sorting and cultured under common conditions. They seem to have comparable properties to bone marrow-derived mesenchymal stem cells in their differentiation abilities as well as a favorable angiogenic and anti-inflammatory cytokine secretion profile and therefore have become widely used in tissue engineering and clinical regenerative medicine.
- Authors BOKU Wien:
- Almeria Ciarra
- Kasper Cornelia
- BOKU Gendermonitor:
- Find related publications in this database (Keywords)
- Adipose-derived stem cells
- ASC
- Fat harvesting
- Isolation protocoll
- Stem cell application
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