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Selected Publication:

Kuhbier, JW; Weyand, B; Radtke, C; Vogt, PM; Kasper, C; Reimers, K.
(2010): Isolation, characterization, differentiation, and application of adipose-derived stem cells.
Adv Biochem Eng Biotechnol. 2010; 123(3):55-105 FullText FullText_BOKU

Abstract:
While bone marrow-derived mesenchymal stem cells are known and have been investigated for a long time, mesenchymal stem cells derived from the adipose tissue were identified as such by Zuk et al. in 2001. However, as subcutaneous fat tissue is a rich source which is much more easily accessible than bone marrow and thus can be reached by less invasive procedures, adipose-derived stem cells have moved into the research spotlight over the last 8 years. Isolation of stromal cell fractions involves centrifugation, digestion, and filtration, resulting in an adherent cell population containing mesenchymal stem cells; these can be subdivided by cell sorting and cultured under common conditions. They seem to have comparable properties to bone marrow-derived mesenchymal stem cells in their differentiation abilities as well as a favorable angiogenic and anti-inflammatory cytokine secretion profile and therefore have become widely used in tissue engineering and clinical regenerative medicine.
Authors BOKU Wien:
Almeria Ciarra
Kasper Cornelia
BOKU Gendermonitor:


Find related publications in this database (Keywords)
Adipose-derived stem cells
ASC
Fat harvesting
Isolation protocoll
Stem cell application


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