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Selected Publication:

Gugerell, A; Neumann, A; Kober, J; Tammaro, L; Hoch, E; Schnabelrauch, M; Kamolz, L; Kasper, C; Keck, M; .
(2015): Adipose-derived stem cells cultivated on electrospun l-lactide/glycolide copolymer fleece and gelatin hydrogels under flow conditions - aiming physiological reality in hypodermis tissue engineering.
Burns. 2015; 41(1):163-171 FullText FullText_BOKU

Abstract:
Introduction: Generation of adipose tissue for bum patients that suffer from an irreversible loss of the hypodermis is still one of the most complex challenges in tissue engineering. Electrospun materials with their micro- and nanostructures are already well established for their use as extracellular matrix substitutes. Gelatin is widely used in tissue engineering to gain thickness and volume. Under conventional static cultivation methods the supply of nutrients and transport of toxic metabolites is controlled by diffusion and therefore highly dependent on size and porosity of the biomaterial. A widely used method in order to overcome these limitations is the medium perfusion of 3D biomaterial-cell-constructs. In this study we combined perfusion bioreactor cultivation techniques with electrospun poly((L)-lactide-co-glycolide) (P(LLG)) and gelatin hydrogels together with adipose-derived stem cells (ASCs) for a new approach in soft tissue engineering.
Authors BOKU Wien:
Almeria Ciarra
Kasper Cornelia
Neumann Anne
BOKU Gendermonitor:


Find related publications in this database (Keywords)
Adipose-derived stem cells
Skin tissue engineering
Scaffold
Bioreactor
Hydrogel
Electrospinning


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