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Selected Publication:

Opietnik, M; Jungbauer, A; Mereiter, K; Rosenau, T.
(2012): Mild Friedel-Crafts Acylation of Furan with Carboxylic Acids and the Heterogeneous Catalyst Couple AlPW12O40 / Mg(OH)(2)
CURR ORG CHEM. 2012; 16(22): 2739-2744.

Abstract:
Many bioactive compounds contain 2-furanoyl moieties. Classical Friedel-Crafts acylation conditions fail completely in the case of the sensitive and polymerization-prone furan, or give only rather unsatisfying yields only. The heterogeneous catalyst couple consisting of equimolar amounts of the stable and non-hygroscopic heteropolyacid aluminum dodecatungstophosphate (AlPW12O40)(1) in combination with Mg(OH)(2) was used for the direct reaction between furan and a variety of free carboxylic acids to regioselectively produce 2-furyl-alkylketones and 2-furyl-arylketones in good to excellent yields. The approach worked even in cases of labile benzofuran and in-dole derivatives where all alternative approaches failed.
Authors BOKU Wien:
Jungbauer Alois
Rosenau Thomas
BOKU Gendermonitor:


Find related publications in this database (Keywords)
Friedel-Crafts-type acylation
AlPW12O40
2-furylketones
furan
green chemistry


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