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Selected Publication:

Yougbare, B; Ouedraogo, D; Tapsoba, ASR; Soudre, A; Zoma, BL; Orozco-terWengel, P; Moumouni, S; Ouedraogo-Kone, S; Wurzinger, M; Tamboura, HH; Traore, A; Mwai, OA; Solkner, J; Khayatzadeh, N; Meszaros, G; Burger, PA.
(2021): Local Ancestry to Identify Selection in Response to Trypanosome Infection in Baoule x Zebu Crossbred Cattle in Burkina Faso
FRONT GENET. 2021; 12, 670390 FullText FullText_BOKU

The genomes of crossbred (admixed) individuals are a mosaic of ancestral haplotypes formed by recombination in each generation. The proportion of these ancestral haplotypes in certain genomic regions can be responsible for either susceptibility or tolerance against pathogens, and for performances in production traits. Using a medium-density genomic marker panel from the Illumina Bovine SNP50 BeadChip, we estimated individual admixture proportions for Baoule x Zebu crossbred cattle in Burkina Faso, which were tested for trypanosome infection by direct ELISA from blood samples. Furthermore, we calculated local ancestry deviation from average for each SNP across 29 autosomes to identify potential regions under selection in the trypanotolerant Baoule cattle and their crossbreds. We identified significant deviation from the local average ancestry (above 5 and 10% genome-wide thresholds) on chromosomes 8 and 19 in the positive animals, while the negative ones showed higher deviation on chromosomes 6, 19, 21, and 22. Some candidate genes on chromosome 6 (PDGFRA) and chromosome 19 (CDC6) have been found associated to trypanotolerance in West African taurines. Screening for F-ST outliers in trypanosome positive/negative animals we detected seven variants putatively under selection. Finally, we identified a minimum set of highly ancestry informative markers for routine admixture testing. The results of this study contribute to a better understanding of the genetic basis of trypanotolerance in Baoule cattle and their crossbreeds. Furthermore, we provide a small informative marker set to monitor admixture in this valuable indigenous breed. As such, our results are important for conserving the genetic uniqueness and trypanotolerance of Baoule cattle, as well as for the improvement of Baoule and Zebu crossbreds in specific community-based breeding programs.

Authors BOKU Wien:
Khayatzadeh Negar
Meszaros Gabor
Sölkner Johann
Wurzinger Maria

Find related publications in this database (Keywords)
local ancestry deviation
selection signature
Burkina Faso

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