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Selected Publication:

Grillari, J; Katinger, H; Voglauer, R; .
(2006): Aging and the ubiquitinome: traditional and non-traditional functions of ubiquitin in aging cells and tissues.
Exp Gerontol. 2006; 41(11):1067-1079 FullText FullText_BOKU

Abstract:
Ubiquitination of endogenous proteins is one of the key regulatory steps of protein degradation followed by regulation of proteasome activity. During the last years evidence has increased that proteasome activity is decreased during the aging process in various model systems and that these changes might be causally related to aging and aging associated diseases. Since in most instances ubiquitination is the primary event in target selection, the system of ubiquitination and deubiquitination might be of similar importance. Furthermore, ubiquitination and proteasomal degradation are not completely congruent, since ubiquitination also confers functions different from giving "the kiss of death" to proteins. Depending on mono- and polyubiquitination and on how ubiquitin chains are linked together, ubiquitination is involved in transcriptional regulation, receptor internalization, DNA repair, and stabilization of protein complexes. This review is therefore the first to summarize. the current knowledge regarding the ubiquitinome and the underlying ubiquitin ligases and deubiquitinating enzymes in replicative senescence, tissue aging as well as in segmental progeroid syndromes and to discuss potential causes and consequences for aging. (c) 2006 Elsevier Inc. All rights reserved.
Authors BOKU Wien:
Grillari Johannes
Grillari Regina
Katinger Hermann
Find related publications in this database (using NML MeSH Indexing)
Aging/genetics;Aging/metabolism;Aging/physiology*;BRCA1 Protein/metabolism;Cell Aging/genetics;Cell Aging/physiology*;Cell Cycle/physiology;Cell Cycle Proteins/metabolism;DNA Repair/genetics;DNA Repair Enzymes/metabolism;Enzyme Activation/physiology;Humans;Nuclear Proteins/metabolism;Progeria/metabolism;Proliferating Cell Nuclear Antigen/metabolism;Signal Transduction/physiology;Telomerase/metabolism;Telomere/physiology;Ubiquitin/physiology*;

Find related publications in this database (Keywords)
ubiquitin
ubiquitinome
aging
replicative senescence
telomeres
DNA repair
progeroid syndrome
BRCA1
PCNA
NF kappa B
p27
SNEV (Prp19/Pso4)


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