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Ferrantelli, F; Buckley, KA; Rasmussen, RA; Chalmers, A; Wang, T; Li, PL; Williams, AL; Hofmann-Lehmann, R; Montefiori, DC; Cavacini, LA; Katinger, H; Stiegler, G; Anderson, DC; McClure, HM; Ruprecht, RM.
(2007): Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques.
Virology. 2007; 358(1):69-78 FullText FullText_BOKU

Abstract:
In a primate model of postnatal virus transmission, we have previously shown that I It post-exposure prophylaxis (PEP) with a triple combination of neutralizing monoclonal antibodies (nmAbs) conferred sterilizing protection to neonatal macaques against oral challenge with pathogenic simian-human immunodeficiency virus (SHIV). Here, we show that nmAbs can also partially protect SHIV-exposed newborn macaques against infection or disease, when given as 12 or 24 h PEP, respectively. This work delineates the potential and the limits of passive immunoprophylaxis with nmAbs. Even though 24 It PEP with nmAbs did not provide sterilizing immunity to neonatal monkeys, it contained viremia and protected infants from acute disease. Taken together with our results from other PEP studies, these data show that the success of passive immunization depends on the nmAb potency/dose and the time window between virus exposure and start of immunotherapy. (c) 2006 Elsevier Inc. All rights reserved.
Authors BOKU Wien:
Katinger Hermann
Find related publications in this database (using NML MeSH Indexing)
Animals -
Animals, Newborn -
Antibodies, Monoclonal - immunology
Antibodies, Viral - blood
CD4 Lymphocyte Count - blood
Disease Models, Animal - blood
HIV Antibodies - immunology
HIV Infections - prevention & control
Immunity, Cellular - prevention & control
Immunization, Passive - prevention & control
Macaca mulatta - prevention & control
Simian Acquired Immunodeficiency Syndrome - prevention & control
Simian immunodeficiency virus - immunology
Survival Analysis - immunology
Time Factors - immunology
Viral Load - immunology
Viremia - immunology

Find related publications in this database (Keywords)
post-exposure prophylaxis
passive immunization
neutralizing monoclonal antibodies
pathogenic simian-human immunodeficiency virus (SHIV)
rhesus macaques
oral infection


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