University of Natural Resources and Life Sciences, Vienna (BOKU) - Research portal
Selected Publication:
Lenz, K; Koellensperger, G; Hann, S; Weissenbacher, N; Mahnik, SN; Fuerhacker, M.
(2007):
Fate of cancerostatic platinum compounds in biological wastewater treatment of hospital effluents.
Chemosphere. 2007; 69(11):1765-1774
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- Abstract:
- The present work focuses on the fate of two cancerostatic platinum compounds (CPC), cisplatin and carboplatin, as well as of two inorganic platinum compounds, [PtCl4](2-) and [PtCl6](2-) in biological wastewater treatment. Laboratory experiments modelling adsorption of these compounds onto activated sludge showed promising specific adsorption coefficients K-D and K-oc and Freundlich adsorption isotherms. However, the adsorption properties of the investigated substances were differing significantly. Adsorption decreased following the order cisplatin > [ptCl(6)](2-) > [PtCl4](2-) > Carboplatin. Log K-D-values were ranging from 2.5 to 4.3, logK(OC) from 3.0 to 4.7. A pilot membrane bioreactor system (MBR) was installed in a hospital in Vienria and fed with wastewater from the oncologic inpatient treatment ward to investigate CPC-adsorption in a sewage treatment plant. During three monitoring periods Pt-concentrations were measured in the influent (3-250 mu g l(-1) Pt) and the effluent (2-150 mu g l(-1) Pt) of the treatment plant using ICP-MS. The monitoring periods (duration 30 d) revealed elimination efficiencies between 51% and 63%, based on averaged weekly input-output budgets. The derived logK(D)-values and logK(OC)-values ranged from 2.4 to 4.8 and from 2.8 to 5.3, respectively. Species analysis using HPLC-ICP-MS proofed that mainly carboplatin was present Lis intact drug in the influent and - due to low log K-D - in the effluent of the MBR. (C) 2007 Elsevier Ltd. All rights reserved.
- Authors BOKU Wien:
- Fürhacker Maria
- Hann Stephan
- Köllensperger Gunda
- Weissenbacher Norbert
- Find related publications in this database (using NML MeSH Indexing)
- Adsorption -
- Antineoplastic Agents - analysis
- Bioreactors - microbiology
- Hospitals -
- Medical Waste Disposal - instrumentation
- Organoplatinum Compounds - analysis
- Pilot Projects -
- Platinum Compounds - analysis
- Sewage - microbiology
- Water Pollutants, Chemical - analysis
- Find related publications in this database (Keywords)
- hospital wastewater
- cancerostatic platinum compounds
- activated sludge
- adsorption
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