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Selected Publication:

Lenz, K; Mahnik, SN; Weissenbacher, N; Mader, RM; Krenn, P; Hann, S; Koellensperger, G; Uhl, M; Knasmüller, S; Ferk, F; Bursch, W; Fuerhacker, M.
(2007): Monitoring, removal and risk assessment of cytostatic drugs in hospital wastewater.
Water Sci Technol. 2007; 56(12):141-149 FullText FullText_BOKU

Abstract:
Cytostatic agents are applied in cancer therapy and subsequently excreted into hospital wastewater. As these substances are known to be carcinogenic, mutagenic and toxic for reproduction, they should be removed from wastewater at their source of origin. In this study the fate and effects of the cancerostatic platinum compounds (CPC) cisplatin, carboplatin, oxaliplatin, 5-fluorouracil (5-FU) and the anthracyclines doxorubicin, daunorubicin and epirubicin were investigated in hospital wastewater. Wastewater from the in-patient treatment ward of a hospital in Vienna was collected and monitored for the occurrence of the selected drugs. A calculation model was established to spot the correlation between administered dosage and measured concentrations. To investigate the fate of the selected substances during wastewater treatment, the oncologic wastewater was treated in a pilot membrane bioreactor system (MBR) and in downstream advanced wastewater treatment processes ( adsorption to activated carbon and UV-treatment). Genotoxic effects of the oncologic wastewater were assessed before and after wastewater treatment followed by a risk assessment. Monitoring concentrations of the selected cytostatics in the oncologic wastewater were in line with calculated concentrations. Due to different mechanisms (adsorption, biodegradation) in the MBR-system 5-FU and the anthracyclines were removed, LOD, whereas CPC were removed by 60%. In parallel, genotoxic effects could be reduced significantly by the MBR-system. The risk for humans, the aquatic and terrestrial environment by hospital wastewater containing cytostatic drugs was classified as small in a preliminary risk assessment.
Authors BOKU Wien:
Fürhacker Maria
Hann Stephan
Köllensperger Gunda
Weissenbacher Norbert
Find related publications in this database (using NML MeSH Indexing)
Bioreactors -
Cytostatic Agents - analysis
Environmental Monitoring - methods
Hospitals -
Medical Waste Disposal - methods
Risk Assessment - methods
Waste Disposal, Fluid - methods
Water Pollutants, Chemical - analysis

Find related publications in this database (Keywords)
advanced wastewater treatment processes
cytostatic agents
hospital wastewater
membrane bioreactor system (MBR)
risk assessment


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