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Stukova, MA; Sereinig, S; Zabolotnyh, NV; Ferko, B; Kittel, C; Romanova, J; Vinogradova, TI; Katinger, H; Kiselev, O; Egorov, A.
(2006): Vaccine potential of influenza vectors expressing Mycobacterium tuberculosis ESAT-6 protein

We generated several attenuated recombinant influenza A vectors expressing the Mycobacterium tuberculosis early secretory antigenic target (ESAT-6) protein. The ESAT-6 protein was recently identified as one of the most promising protective antigens for cell-mediated immunity. The obtained vectors appeared to be capable of inducing ESAT-6 specific Th1 immune response in mice after intranasal immunization. We found that double immunization with two influenza vectors of different subtypes provided a significant level of protection in mice, when applied as prophylactic vaccine, as well as substantial therapeutic effect in mice with preestablished tuberculosis infection. Moreover, we found a strong synergistic effect when vaccination with Flu/ESAT-6 vectors was combined with isoniazid treatment, resulting in a dramatic reduction of bacterial. toad in the lungs of infected mice. (c) 2006 Elsevier Ltd. All rights reserved.
Authors BOKU Wien:
Katinger Hermann
Find related publications in this database (using NML MeSH Indexing)
Administration, Intranasal -
Animals -
Antigens, Bacterial - genetics
Antitubercular Agents - therapeutic use
Bacterial Proteins - genetics
Combined Modality Therapy -
Genetic Vectors - administration & dosage
Immunity, Cellular -
Immunization - methods
Influenza A virus - genetics
Isoniazid - therapeutic use
Mice -
Mice, Inbred C57BL -
Mycobacterium tuberculosis - immunology
Th1 Cells - immunology
Tuberculosis - immunology
Tuberculosis Vaccines - immunology

Find related publications in this database (Keywords)
tuberculosis vaccine

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