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Lawen, A; Ly, JD; Lane, DJ; Zarschler, K; Messina, A; De Pinto, V.
(2005): Voltage-dependent anion-selective channel 1 (VDAC1)--a mitochondrial protein, rediscovered as a novel enzyme in the plasma membrane.
Int J Biochem Cell Biol. 2005; 37(2):277-282 FullText FullText_BOKU

Abstract:
The eukaryotic porin or voltage-dependent anion-selective channel (VDAC1) is a pore-forming protein discovered twenty five years ago in the mitochondrial outer membrane. Its gene in eukaryotes is known, but its tertiary structure has never been solved. Structure predictions highlight the presence of several amphipathic beta-strands possibly organised in a beta-barrel. VDAC1 has recently been described as being a NADH:ferricyanide reductase in the plasma membrane. There it affects the regulation of cell growth and death. Physiological cell death (apoptosis) has become a major research focus of biomedical research. Regulation of the enzyme will have impacts on cancer and autoimmune diseases (insufficient apoptosis) as well as neurodegenerative diseases (excessive apoptosis). VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity. (C) 2004 Elsevier Ltd. All rights reserved.
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Find related publications in this database (using NML MeSH Indexing)
Animals -
Apoptosis - immunology
Autoimmune Diseases - immunology
Humans -
Intracellular Membranes - enzymology
Mitochondria - enzymology
NADH, NADPH Oxidoreductases - chemistry
Neoplasms - immunology
Neurodegenerative Diseases - immunology
Oxidation-Reduction -
Porins - chemistry
Protein Structure, Secondary -
Protein Structure, Tertiary -
Signal Transduction - immunology
Voltage-Dependent Anion Channel 1 -
Voltage-Dependent Anion Channels -

Find related publications in this database (Keywords)
VDAC1
plasma membrane NADH
ferricyanide reductase
redox homeostasis
apoptosis


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