University of Natural Resources and Life Sciences, Vienna (BOKU) - Research portal
Selected Publication:
Korzhikov, V; Roeker, S; Vlakh, E; Kasper, C; Tennikova, T.
(2008):
Synthesis of multifunctional polyvinylsaccharide containing controllable amounts of biospecific ligands.
Bioconjug Chem. 2008; 19(3):617-625
FullText
FullText_BOKU
- Abstract:
- In the present study, the attempt to synthesize a multibiofunctional polymeric vector to be used for construction of composite scaffolds for bone tissue engineering has been undertaken. The polymers based on 2-deoxy-2-methacrylamido-D-glucose were functionalized by a growth factor (BMP-2), GRGDSP peptide, and poly(L-lysine) using aldehyde chemistry. The covalent modification process was quantitatively studied, and a polymer conjugate containing all these ligands was formed. In addition, the impacts of coupled ligands toward the adsorption of polymers on the commercial mineral macroporous matrix Sponceram used in cell culture applications were studied.
- Authors BOKU Wien:
- Almeria Ciarra
- Kasper Cornelia
- Find related publications in this database (using NML MeSH Indexing)
- 3T3 Cells -
- Adsorption -
- Aldehydes - chemistry
- Animals -
- Bone Morphogenetic Protein 2 -
- Bone Morphogenetic Proteins - chemistry
- Cell Survival - drug effects
- Electrophoresis, Polyacrylamide Gel -
- Humans -
- Indicators and Reagents -
- Kinetics -
- Ligands -
- Mice -
- Oligopeptides - chemistry
- Polylysine - chemistry
- Polysaccharides - chemical synthesis
- Polyvinyls - chemical synthesis
- Ribonuclease, Pancreatic - metabolism
- Ribonucleases - chemistry
- Spectrophotometry, Ultraviolet -
- Tetrazolium Salts -
- Thermodynamics -
- Thiazoles -
- Tissue Engineering -
- Transforming Growth Factor beta - chemistry
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