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Sarkanj, B; Warth, B; Uhlig, S; Abia, WA; Sulyok, M; Klapec, T; Krska, R; Banjari, I.
(2013): Urinary analysis reveals high deoxynivalenol exposure in pregnant women from Croatia
FOOD CHEM TOXICOL. 2013; 62: 231-237. FullText FullText_BOKU

Abstract:
In this pilot survey the levels of various mycotoxin biomarkers were determined in third trimester pregnant women from eastern Croatia. First void urine samples were collected and analysed using a "dilute and shoot" LC-ESI-MS/MS multi biomarker method. Deoxynivalenol (DON) and its metabolites: deoxynivalenol-15-glucuronide and deoxynivalenol-3-glucuronide were detected in 97.5% of the studied samples, partly at exceptionally high levels, while ochratoxin A was found in 10% of the samples. DON exposure was primarily reflected by the presence of deoxynivalenol-15-glucuronide with a mean concentration of 120 mu g L-1, while free DON was detected with a mean concentration of 18.3 mu g L-1. Several highly contaminated urine samples contained a third DON conjugate, tentatively identified as deoxynivalenol-7-glucuronide by MS/MS scans. The levels of urinary DON and its metabolites measured in this study are the highest ever reported, and 48% of subjects were estimated to exceed the provisional maximum tolerable daily intake (1 mu g kg(-1) b.w.). (C) 2013 Elsevier Ltd. All rights reserved.
Authors BOKU Wien:
Krska Rudolf
Sulyok Michael
Warth Benedikt
BOKU Gendermonitor:

Find related publications in this database (using NML MeSH Indexing)
Adult
Biomarkers/urine*
Croatia
Environmental Exposure/analysis*
Female
Food Contamination/analysis
Glucuronides/urine
Humans
Mycotoxins/toxicity
Mycotoxins/urine
Ochratoxins/toxicity
Ochratoxins/urine
Pregnancy
Pregnancy Trimester, Third
Trichothecenes/urine*

Find related publications in this database (Keywords)
Mycotoxins
Deoxynivalenol glucuronide
Biomarker
Pregnant women
Human urine
Croatia


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