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Abia, WA; Warth, B; Sulyok, M; Krska, R; Tchana, A; Njobeh, PB; Turner, PC; Kouanfack, C; Eyongetah, M; Dutton, M; Moundipa, PF.
(2013): Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach
FOOD CHEM TOXICOL. 2013; 62: 927-934. FullText FullText_BOKU

Abstract:
Bio-monitoring of human exposure to mycotoxin has mostly been limited to a few individually measured mycotoxin biomarkers. This study aimed to determine the frequency and level of exposure to multiple mycotoxins in human urine from Cameroonian adults. 175 Urine samples (83% from HIV-positive individuals) and food frequency questionnaire responses were collected from consenting Cameroonians, and analyzed for 15 mycotoxins and relevant metabolites using LC-ESI-MS/MS. In total, eleven analytes were detected individually or in combinations in 110/175 (63%) samples including the biomarkers aflatoxin M-1, fumonisin B-1, ochratoxin A and total deoxynivalenol. Additionally, important mycotoxins and metabolites thereof, such as fumonisin B-2, nivalenol and zearalenone, were determined, some for the first time in urine following dietary exposures. Multi-mycotoxin contamination was common with one HIV-positive individual exposed to five mycotoxins, a severe case of co-exposure that has never been reported in adults before. For the first time in Africa or elsewhere, this study quantified eleven mycotoxin biomarkers and bio-measures in urine from adults. For several mycotoxins estimates indicate that the tolerable daily intake is being exceeded in this study population. Given that many mycotoxins adversely affect the immune system, future studies will examine whether combinations of mycotoxins negatively impact Cameroonian population particularly immune-suppressed individuals. (C) 2013 Elsevier Ltd. All rights reserved.
Authors BOKU Wien:
Krska Rudolf
Sulyok Michael
Warth Benedikt
BOKU Gendermonitor:

Find related publications in this database (using NML MeSH Indexing)
Adolescent
Adult
Biomarkers/urine*
Cameroon
Environmental Exposure/analysis*
Environmental Monitoring/methods
Feeding Behavior*
Female
Food Contamination
Fumonisins/urine
Glucuronides/urine
Humans
Male
Middle Aged
Mycotoxins/toxicity
Mycotoxins/urine*
No-Observed-Adverse-Effect Level
Ochratoxins/urine
Surveys and Questionnaires
Trichothecenes/urine
Young Adult
Zearalenone/analogs & derivatives
Zearalenone/urine

Find related publications in this database (Keywords)
Bio-monitoring
Bio-measures
Cameroon
Exposure assessment
HIV/AIDS
Multi-mycotoxin biomarkers


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