Diagnosis and prevention of the PSSM hereditary muscular disorder in breeding of Austrian Noriker and Haflinger horses
Abstract
Polysaccharid-Storage-Myopathy (PSSM) is a muscular defect in horses that causes distress. A mutation of the gene GYS1 is involved but animals without the mutations also show the condition. In this project, the genetic background of the condition is explored by high throughput genotyping and sequencing. The muscular activity of a large sample of horses is checked using electro-myography (EMG) at rest, in walk and trot to find whether EMG may serve as biomarker for PSSM-susceptibility. Animals that have shown already the PSSM condition are actively sought. For the establishment of breeding plans, the genetic structure of Norker and Haflinger populations is investigated using high throughput marker data. Individual inbreeding levels are calculated to provide information whether exclusion of carriers of the GYS1-mutation is harmful for trhe populations. Alternative strategies of reduction of PSSM prevalence are discussed with breeding organizations.
keywords PSSM Horse Genetic diveristy Muscular activity
Publikationen
Project staff
Johann Sölkner
Univ.Prof. Dipl.-Ing. Dr.nat.techn. Johann Sölkner
johann.soelkner@boku.ac.at
Tel: +43 1 47654-93201, 93231
Project Leader
01.09.2016 - 31.03.2018