CD-Laboratory for Skin Multimodal Analytical Imaging of Aging and Senescence
Abstract
Aging of the skin is the most visible and obvious manifestation of organismal aging and serves as a predictor of life expectancy and health even to the layperson. It is however also the human desire for long-lasting beauty that further raises broad interest in the topic as a field of basic and applied research. Modern urban lifestyle involves exposure to pollution combined with recreational outdoor exposure to sun, and both are major external promotors of skin aging. Moreover, the age-associated accumulation of senescent cells is a major cause for visible signs of skin aging, while pollution and sunlight further promote cellular senescence. The skin is an ideal organ to observe and analyze the impact of extrinsic and intrinsic drivers of aging. It is accessible not only to classical biochemical and immunohistochemical methods of analysis, but also, as it defines the outside of the body, to non- or minimally invasive methods of investigation. The recent years have brought an explosion of analytical capability in both classical and minimally invasive methods, which we will combine within this CD laboratory to analyze how the urban exposome and senescent cells affect skin metabolism, communication and quality control. We will use a multimodal approach, the combination of various pioneering analytical imaging techniques, to investigate the initiation, promotion and chronic phases of cellular senescence in skin aging. Furthermore, we will also analyze and visualize the contribution of senescent cells to the deterioration of local microenvironments, which will promote a better understanding of the essential events in skin aging. Importantly, this visual and analytic approach allows investigating active substances for skincare that prevent or reverse deterioration of cellular metabolism and quality control.
keywords cellular senescence skin aging multimodal imaging biogerontology RNA biology
Publikationen
Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control.
Autoren: Cavinato, M; Madreiter-Sokolowski, CT; Büttner, S; Schosserer, M; Zwerschke, W; Wedel, S; Grillari, J; Graier, WF; Jansen-Dürr, P; Jahr: 2021
Journal articles
Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors.
Autoren: Narzt, MS; Pils, V; Kremslehner, C; Nagelreiter, IM; Schosserer, M; Bessonova, E; Bayer, A; Reifschneider, R; Terlecki-Zaniewicz, L; Waidhofer-Söllner, P; Mildner, M; Tschachler, E; Cavinato, M; Wedel, S; Jansen-Dürr, P; Nanic, L; Rubelj, I; El-Ghalbzouri, A; Zoratto, S; Marchetti-Deschmann, M; Grillari, J; Gruber, F; Lämmermann, I; Jahr: 2021
Journal articles
The role of lipid-based signalling in wound healing and senescence.
Autoren: Pils, V; Terlecki-Zaniewicz, L; Schosserer, M; Grillari, J; Lämmermann, I; Jahr: 2021
Journal articles
Promises and challenges of senolytics in skin regeneration, pathology and ageing.
Autoren: Pils, V; Ring, N; Valdivieso, K; Lämmermann, I; Gruber, F; Schosserer, M; Grillari, J; Ogrodnik, M; Jahr: 2021
Journal articles
Raman microspectroscopy: sub-cellular chemical imaging of aging.
Autoren: Liendl, L; Schosserer, M; Jahr: 2021
Journal articles
The role and biology of senescent cells in ageing-related tissue damage and repair.
Autoren: Schosserer, M; Jahr: 2022
Journal articles
Project staff
Johannes Grillari
Assoc. Prof. Dr. Johannes Grillari
johannes.grillari@boku.ac.at
Tel: +43 1 47654-79067
BOKU Project Leader
12.10.2022 - 31.12.2022
Markus Schosserer
Dipl.-Ing. Dr. Markus Schosserer
markus.schosserer@boku.ac.at
Tel: +43 1 47654-79067
BOKU Project Leader
01.09.2020 - 11.10.2022
Lisa Liendl
Mag. Lisa Liendl
Tel: +43 1 47654-79048, 79050, 79057
Project Staff
01.09.2020 - 31.12.2021
Vera Pils
Vera Pils B.Sc.
vera.pils@boku.ac.at
Tel: +43 1 47654-35085
Project Staff
01.08.2021 - 01.02.2022
Maximilian Schmid-Siegel
Mag.pharm. Maximilian Schmid-Siegel
maximilian.schmid-siegel@boku.ac.at
Project Staff
07.02.2022 - 31.03.2025
BOKU partners
External partners
CHANEL Parfums Beauté_x000D_ RCS Neuilly sur Seine (92)
none
partner
Medical University Vienna
Assoc. Prof. Priv.-Doz. Mag. Dr. Florian Gruber
coordinator
Technische Universität Wien
Assoc.Prof. Dr. Martina Marchetti-Deschmann
partner