Development of Carbohydrate Array Technologies to Systematically Explore the Functional role of Glycans in Healthy and Diseased States
- Biotechnologie
- Forschungscluster "Bioindustrielle Technologien"
Abstract
The objective of the proposal is to bring together an interdisciplinary team of scientists and technologists in Europe for the development and application of ‘Glycoarrays’. Glycoarrays are micro-arrays displaying unnatural and natural complex carbohydrate structures, such as those found on cell surfaces and/or attached to proteins and lipids. Such glycoarrays will provide unique tools to identify the many interactions of carbohydrate binding proteins with specific carbohydrate sequences on a cell and organism-wide scale, and thus provide us with a fundamental understanding of these important biological recognition events.
- glycans
Publications
Fucosyltransferases as Synthetic Tools: Glycan Array Based Substrate Selection and Core Fucosylation of Synthetic N-Glycans
Autoren: Serna, S; Yan, S; Martin-Lomas, M; Wilson, IBH; Reichardt, NC Jahr: 2011
Journal articles
Double Mutants as Tools for Elucidating N-glycosylation Pathways in Caenorhabditis elegans
Autoren: Yan, S; Paschinger, K; Bleuler-Martinez, S; Jantsch, V; Wilson, I Jahr: 2011
Journal articles
Double mutants as tools for elucidating N-glycosylation pathways in Caenorhabditis elegans
Autoren: Yan S, Paschinger K, Martinez SB, Jantsch V, Wilson IBH Jahr: 2011
Journal articles
Plasticity of the beta-Trefoil Protein Fold in the Recognition and Control of Invertebrate Predators and Parasites by a Fungal Defence System
Autoren: Schubert, M; Bleuler-Martinez, S; Butschi, A; Walti, MA; Egloff, P; Stutz, K; Yan, S; Wilson, IBH; Hengartner, MO; Aebi, M; Allain, FHT; Kunzler, M Jahr: 2012
Journal articles
Galactosylated Fucose Epitopes in Nematodes INCREASED EXPRESSION IN A CAENORHABDITIS MUTANT ASSOCIATED WITH ALTERED LECTIN SENSITIVITY AND OCCURRENCE IN PARASITIC SPECIES
Autoren: Yan, S; Bleuler-Martinez, S; Plaza, DF; Kunzler, M; Aebi, M; Joachim, A; Razzazi-Fazeli, E; Jantsch, V; Geyer, R; Wilson, IBH; Paschinger, K Jahr: 2012
Journal articles
Array-assisted Characterization of a Fucosyltransferase Required for the Biosynthesis of Complex Core Modifications of Nematode N-Glycans
Autoren: Yan, S; Serna, S; Reichardt, NC; Paschinger, K; Wilson, IBH Jahr: 2013
Journal articles
Analysis of Microarrays by MALDI-TOF MS
Autoren: Beloqui, A; Calvo, J; Serna, S; Yan, S; Wilson, IBH; Martin-Lomas, M; Reichardt, NC Jahr: 2013
Journal articles
Project staff
Iain B.H. Wilson
Ao.Univ.Prof. Dr.phil. Iain B.H. Wilson
iain.wilson@boku.ac.at
Tel: +43 1 47654-77216, 77217
BOKU Project Leader
01.09.2008 - 31.08.2012
Shi Yan
Mag.rer.nat. Dr.nat.techn. Shi Yan
shi.yan@boku.ac.at
Tel: +43 1 47654-77222
Project Staff
01.09.2008 - 31.08.2012
BOKU partners
External partners
The University of Manchester
Prof. Sabine Flitsch
coordinator