Investigating the plasticity of viral envelope proteomes
Abstract
Summary This project investigates the hypothesis that a virus dynamically tunes the composition of proteins associated to its envelope in order to control the response of its host organism. We intend to test for association of GPI anchored proteins to envelopes, but on a more general level also for association of any proteins to the virus post-exit, i.e. in circulation. Studies investigating this have not been undertaken so far. We believe that gathering information on such mechanisms will help to identify a new aspect of host-pathogen interaction, since the mechanisms investigated may very well be of great importance for success of viral transmission. Subsequently, this research could also open new routes for anti-viral intervention, perhaps especially in the context of zoonotic or emerging infections.
keywords Proteomics Viral envelopes Influenza Model membrane HIV
Publikationen
Project staff
Erik Reimhult
Univ.Prof. Dr. Erik Reimhult
erik.reimhult@boku.ac.at
Tel: +43 1 47654-80211
BOKU Project Leader
15.04.2013 - 14.04.2016
BOKU partners
External partners
University of Veterinary Medicine Vienna
none
partner