Lukas Mach
Univ.Prof. Dipl.-Ing. Dr. Lukas Mach
Institut für Pflanzenbiotechnologie und Zellbiologie
Standort Muthgasse 18, 1190 Wien
Email lukas.mach@boku.ac.at
Tel: +43 1 47654-94065, 94360
Forschungsschwerpunkt
Biosynthese und intrazellulärer Transport von sekretorischen und lysosomalen/vakuolären Proteinen, Glykosylierung und andere posttranslationale Proteinmodifikationen als Determinanten von Proteinstruktur und -funktion, katalytische Eigenschaften und physiologische Funktionen von Proteasen und Glykosylierungsenzymen, Proteolyse und ihre pathologische und biotechnologische Bedeutung, rekombinante Expression von Biotherapeutika in Pflanzen und Insektenzellen.
Laufbahn
- 2018 Universitätsprofessor für Zellbiologie, Department für Angewandte Genetik und Zellbiologie, Universität für Bodenkultur Wien
- 2010 - 2014 Leiter des Departments für Angewandte Genetik und Zellbiologie, Universität für Bodenkultur Wien
- 2004 - 2018 Außerordentlicher Universitätsprofessor am Institut für Angewandte Genetik und Zellbiologie, Universität für Bodenkultur Wien
- 1999 - 2004 Universitätsassistent am Zentrum für Angewandte Genetik, Universität für Bodenkultur Wien
- 1995 - 1999 Universitätsassistent ("Lecturer") am Dept. of Biochemistry, University of Western Australia, Nedlands, Australia
- 1994 - 1995 Wissenschaftlicher Mitarbeiter, Abteilung für immunologische Forschung, IMMUNO AG, Vienna
- 1989 - 1994 Dissertant (McGill University, Montreal, Kanada; Universität für Bodenkultur Wien)
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Vorträge
Jahr: 2022 - Factors defining the proteolytic susceptibility of monoclonal antibodies in the tobacco apoplast
Autoren: Mach, L
Veranstaltung: 5th Conference on Plant Proteases
Jahr: 2015 - Unable to express one of leptospiral genes of leucine-rich repeat protein in Lactobacillus plantarum
Autoren: Suphatpahirapol, C; Nguyen, TH; Mach, L; Nitipane, S; Wajjwalku, W; Keawsompong, S; Haltrich, D; Prapong, S
Veranstaltung: Eigth Asian Conference for Lactic Acid Bacteria ACLAB 2015
Jahr: 2014 - Proteolysis of Anti-HIV Antibodies Manufactured in Nicotiana Benthamiana: Identification and Characterization of Antibody-Degrading Papain-Like Cysteine Proteinases
Autoren: Niemer, M; Mehofer, U; Verdianz, M; Porodko, A; Schähs, P; Kracher, D; van der Hoorn, R; Lenarcic, B; Novinec, M; Mach, L
Veranstaltung: 14th International Symposium on Proteinases, Inhibitors and Biological Control 2014
Jahr: 2014 - The Human Anti-HIV Antibodies 2F5, PG9 and 2G12 Differ in Their Proteolytic Susceptibility
Autoren: Niemer, M; Mehofer, U; Torres Acosta, JA; Verdianz, M; Henkel, T; Loos, A; Strasser, R; Maresch, D; Rademacher, T; Steinkellner, H; Mach, L
Veranstaltung: 16th European Congress on Biotechnology 2014
Jahr: 2014 - The Human Anti-HIV Antibodies 2F5, PG9 and 2G12 Differ in Their Proteolytic Susceptibility
Autoren: Niemer, M; Mehofer, U; Torres Acosta, JA; Verdianz, M; Henkel, T; Loos, A; Strasser, R; Maresch, D; Rademacher, T; Steinkellner, H; Mach, L
Veranstaltung: 6th ÖGMBT Annual Meeting 2014 - Life Sciences meet Entrepreneurship
Jahr: 2013 - Characterization of three Nicotiana benthamiana papain-like cysteine proteinases
Autoren: Niemer, M; Mehofer, U; Verdianz, M; Porodko, A; Schähs, P; van der Hoorn, R; Mach, L
Veranstaltung: 25th Winter School on Proteinases and Their Inhibitors 2013
Jahr: 2013 - Characterization of TF0955 – a putative protease of the oral pathogen Tannerella forsythia
Autoren: Tomek, M; Friedrich, V; Potempa, J; Messner, P; Mach, L; Schäffer, C
Veranstaltung: 25th Winter School on Proteinases and Their Inhibitors 2013
Jahr: 2013 - Cathepsin L is involved in the proteolytic processing and turnover of Drosophila melanogaster Cellular Repressor of E1A-stimulated Genes
Autoren: Nimmerfall, E; Schähs, P; Mach, L
Veranstaltung: 25th Winter School on Proteinases and Their Inhibitors 2013
Jahr: 2013 - The role of the mannose 6-phosphate/insulin-like growth factor II receptor and its ligands in cancer cell invasion
Autoren: Mach, L
Veranstaltung: Colloquia in Chemical Sciences, University of Ljubljana
Jahr: 2013 - Characterization of Nicotiana benthamiana papain-like cysteine proteinases
Autoren: Niemer, M; Mehofer, U; Verdianz, M; Porodko, A; Schähs, P; van der Hoorn, R; Mach, L
Veranstaltung: 8th General Meeting of the International Proteolysis Society 2013
Jahr: 2012 - Cathepsin L is involved in the proteolytic maturation and turnover of Drosophila melanogaster Cellular Repressor of E1A-stimulated Genes
Autoren: Nimmerfall, E; Schähs, P; Mach, L
Veranstaltung: 13th International Symposium on Proteinases, Inhibitors and Biological Control 2012
Jahr: 2012 - Characterization of three Nicotiana benthamiana papain-like cysteine proteinases
Autoren: Niemer, M; Mehofer, U; Verdianz, M; Porodko, A; Schähs, P; van der Hoorn, R; Mach, L
Veranstaltung: 13th International Symposium on Proteinases, Inhibitors and Biological Control 2012
Jahr: 2012 - Degradation of recombinant proteins by plant cysteine proteinases
Autoren: Niemer, M; Mehofer, U; Verdianz, M; Schaller, A; van der Hoorn, R; Mach, L
Veranstaltung: FA0804 COST Action Molecular farming 2012 -Plants as a production platform for high value proteins
Jahr: 2012 - Human cathepsin O: glycosylation, processing and cellular activity
Autoren: Aufy, M; Porodko, A; Stadlmann, J; Gruber, C; Mach, L
Veranstaltung: 13th International Symposium on Proteinases, Inhibitors and Biological Control 2012
Jahr: 2012 - Degradation of recombinant proteins expressed in plants by papain-like cysteine proteinases
Autoren: Niemer, M; Mehofer, U; Verdianz, M; Schaller, A; van der Hoorn, R; Mach, L
Veranstaltung: 29th Winter School on Proteinases and Their Inhibitors 2012
Jahr: 2011 - Degradation of recombinant monoclonal antibodies by plant cysteine proteinases
Autoren: Mach, L.
Veranstaltung: 1st International Plant Protease Conference 2011
Jahr: 2011 - The human lysosomal cysteine protease cathepsin O is N- and O-glycosylated
Autoren: Aufy, M., Porodko, A., Stadlmann, J., Mach, L.
Veranstaltung: 21st International Symposium on Glycoconjugates GLYCO 21, 2011
Jahr: 2011 - Biosynthesis, intracellular transport and subcellular localization of human cathepsin O
Autoren: Aufy, M., Nimmerfall, E., Mach, L.
Veranstaltung: 28th Winter School on Proteinases and Their Inhibitors 2011
Jahr: 2011 - Role of N-glycosylation for the activity of the Arabidopsis thaliana endo-1,4-beta-glucanase KORRIGAN1
Autoren: Liebminger, E., Grass, J., Altmann, F., Mach, L., Strasser, R.
Veranstaltung: 21st International Symposium on Glycoconjugates GLYCO 21, 2011
Jahr: 2011 - The role of the mannose 6-phosphate/IGF-II receptor and it's diverse ligands in cancer cell invasion
Autoren: Mach, L.
Veranstaltung: ICA Symposium 2011
Jahr: 2011 - The two N-glycans of murine Cellular Repressor of E1A-stimulated Genes (CREG) are both engaged in lysosomal sorting of the protein
Autoren: Schähs, P., Schönbacher, A., Steinschauer, V., Porodko, A., Stadlmann, J., Mach, L.
Veranstaltung: 21st International Symposium on Glycoconjugates GLYCO 21, 2011
Jahr: 2011 - Antonio Baici and the mysteries of tumour cathepsin B
Autoren: Mach, L.
Veranstaltung: Symposium in the honour of Antonio Baici and Heinz Gehring, University of Zürich 2011
Jahr: 2010 - Characterization of Drosophila melanogaster cellular repressor of E1A-stimulated genes (CREG)
Autoren: Schähs, P., Mach, L.
Veranstaltung: 2nd ÖGMBT Annual Meeting 2010
Jahr: 2010 - Biosynthesis, intracellular transport and subcellular localization of human cathepsin O
Autoren: Aufy, M., Nimmerfall, E., Mach, L.
Veranstaltung: 12th Symposium on Proteases, Inhibitors and Biological Control 2010
Jahr: 2010 - Biosynthesis, intracellular transport and subcellular localization of human cathepsin O
Autoren: M. Aufy, E. Nimmerfall, L.Mach
Veranstaltung: 2nd ÖGMBT Annual Meeting 2010
Jahr: 2009 - Consistent1,4-galactosylation of monoclonal antibodies produced in plants.
Autoren: Castilho, A., Strasser, R., Stadlmann, J., Kunert, R., Gattinger, P., Altmann, F., Mach, L., Steinkellner, H
Veranstaltung: 15th European Carbohydrate Symposium 2009
Jahr: 2009 - Cloning, expression and purification of human recombinant lactoperoxidase
Autoren: Stampler, J., Furtmüller, P.G., Soudi, M., Mach, L., Obinger, C.
Veranstaltung: 6th International Human Peroxidase Meeting 2009
Jahr: 2009 - Characterization of the beta1,3-galactosyltransferase indispensable for the modification of Arabidopsis N-glycans with Lewis A epitopes.
Autoren: Strasser, R., Vavra, U., Schoberer, J., Svoboda, B., Glössl, J., Leonard, R., Altmann, F., Steinkellner, H., Mach, L.
Veranstaltung: 15th European Carbohydrate Symposium 2009
Jahr: 2009 - Role of β-N-acetylhexosaminidases in the formation of paucimannosidic N-glycans in plants
Autoren: Glössl, J., Liebminger, E., Schoberer, J., Svoboda, B., Altmann, F., Steinkellner, H., Mach, L., Strasser, R.
Veranstaltung: GLYCOBIOLOGY 2009
Jahr: 2009 - Characterization of the beta1,3-galactosyltransferase indispensable for the modification of Arabidopsis N-glycans with Lewis A epitopes.
Autoren: Strasser, R., Vavra, U., Schoberer, J., Svoboda, B., Glössl, J., Leonard, R., Altmann, F., Steinkellner, H., Mach, L.
Veranstaltung: 15th European Carbohydrate Symposium 2009
Jahr: 2009 - Role of Arabidopsis β-N-acetylhexosaminidases in the formation of paucimannosidic N-glycans.
Autoren: Liebminger, E., Schoberer, J., Svoboda, B., Glössl, J., Altmann, F., Steinkellner, H., Mach, L., Strasser, R.
Veranstaltung: 15th European Carbohydrate Symposium 2009
Jahr: 2009 - Glyco-engineering in plants: production of monoclonal antibodies containing homogeneously β1,4-galactosylated human-type N-glycans.
Autoren: Glössl, J., Strasser, R., Castilho, A., Kunert, R., Altmann, F., Mach, L., Steinkellner, H.
Veranstaltung: GLYCOBIOLOGY 2009
Jahr: 2008 - Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis
Autoren: Schähs, P., Weidinger, P., Probst, O.C., Svoboda, B., Stadlmann, J., Beug, H., Waerner, T., Mach, L.
Veranstaltung: 11th Symposium on Proteinase Inhibitors and Biological Control 2008
Jahr: 2008 - Lysosomal proteinases and their receptors: the ability of M6P/IGF2R to bind mannose 6-phosphate is critical for its capacity to restrict the invasiveness of tumour cells
Autoren: Probst, O.C., Puxbaum, V., Karayel, E., Bäuerl, C., Schida, N., Svoboda, B., Mach, L.
Veranstaltung: 11th Symposium on Proteinase Inhibitors and Biological Control 2008
Jahr: 2008 - Cellular Repressor of E1A-stimulated Genes (CREG) is a lysosomal protein which undergoes proteolytic maturation during its biosynthesis
Autoren: Schähs, P., Weidinger, P., Probst, O.C., Svoboda, B., Stadlmann, J., Beug, H., Waerner, T., Mach, L.
Veranstaltung: Joint Annual Meeting of ÖGBM, ÖGGGT, ÖGBT and ANGT Life Science 2008
Jahr: 2008 - Characterization of the beta1,3-galactosyltransferase indispensable for the modification of plant N-glycans with Lewis a epitopes
Autoren: Strasser, R., Vavra, U., Schoberer, J., Svoboda, B., Glössl, J., Léonard, R., Stadlmann, J., Altmann, F., Steinkellner, H., Mach, L.
Veranstaltung: 6th International Conference on Glycosyltransferases GlycoT 2008
Jahr: 2008 - Role of Arabidopsis beta-N-acetylhexosaminidases in the formation of paucimannosidic N-glycans
Autoren: Liebminger, E., Schoberer, J., Svoboda, B., Glössl, J., Altmann, F., Steinkellner, H., Mach, L., Strasser, R.
Veranstaltung: 26th Congress of the Federation of European Societies of Plant Biology FESPB 2008 tohether with 11th annual international meeting for experimental moss research and 8th International Peroxidase Symposium, Peroxidase 2008
Jahr: 2008 - The M6P/IGF2 receptor restricts the invasiveness of liver tumor cells by controlling pericellular proteolysis
Autoren: Puxbaum, V., Bäuerl, C., Taub, N., Wieser, J., Maurer, P.M., Mikula, M., Mikulits, W., Mach, L.
Veranstaltung: Joint Annual Meeting of ÖGBM, ÖGGGT, ÖGBT and ANGT Life Science 2008
Jahr: 2008 - The mannose 6-phosphate/insulin-like growth factor II receptor restricts the invasiveness of liver tumor cells by controlling pericellular proteolysis
Autoren: Puxbaum V., Bäuerl C., Taub N., Wieser J., Maurer P.M., Mikula M., Mikulits W., Mach L.
Veranstaltung: Gordon Research Conference on Proteolytic Enzymes and their Inhibitors 2008
Jahr: 2007 - A NOVEL beta1,3-GALACTOSYLTRANSFERASE IS INDISPENSABLE FOR THE BIOSYNTHESIS OF COMPLEX N-GLYCANS IN PLANTS
Autoren: Strasser, R., Bondili, J.S., Vavra, U., Schoberer, J., Svoboda, B., Glössl, J., Léonard, R., Stadlmann, J., Altmann, F., Steinkellner, H., Mach, L.
Veranstaltung: 4th Tri-National Arabidopsis Meeting TNAM 2007
Jahr: 2007 - Engineering of the N-Glycosylation Pathway in the Model Plant Arabidopsis thaliana
Autoren: Glössl, J., Castilho, A., Schähs, M., Strasser, R., Pabst, M., Leonard, R., Mach, L., Altmann, F., Steinkellner, H.
Veranstaltung: 19th International Symposium on Glycoconjugates Glyco 19 2007
Jahr: 2007 - A novel beta1,3-galactosyltransferase indispensable for the modification of plant N-glycans with Lewis a epitopes
Autoren: Strasser, R., Bondili, J.S., Vavra, U., Schoberer, J., Svoboda, B., Glössl, J., Leonard, R., Stadlmann, J., Altmann, F., Steinkellner, H., Mach, L.
Veranstaltung: 19th International Symposium on Glycoconjugates Glyco 19 2007
Jahr: 2007 - Engineering of the N-Glycosylation Pathway in the Model Plant Arabidopsis thaliana
Autoren: Glössl, J., Castilho, A., Schähs, M., Strasser, R., Pabst, M., Leonard, R., Mach, L., Altmann, F., Steinkellner, H.
Veranstaltung: PSE Congress 2007 - Plants for Human Health in the Post-Genome Era
Jahr: 2007 - Enzymatic Properties and Subcellular Localization of Arabidopsis beta-N-acetylhexosaminidases
Autoren: Eva Liebminger, Jayakumar Singh Bondili, Jennifer Schoberer, Friedrich Altmann, Josef Glössl, Herta Steinkellner, Lukas Mach, Richard Strasser
Veranstaltung: 32nd Congress of the Federation of European Biochemical Societies FEBS 2007 - Molecular Machines
Jahr: 2006 - Glycoengineered plants for the production of recombinant glycoproteins with humanized N-glycosylation
Autoren: Glossl, J; Strasser, R; Schahs, M; Stadlmann, J; Altmann, F; Mach, L; Steinkellner, H
Veranstaltung: Meeting of the Society for Glycobiology 2006
Jahr: 2006 - Control of complex N-glycan biosynthesis in plants: sequence motifs required for Golgi localisation of N-glycan processing enzymes
Autoren: Richard Strasser, Jennifer Schoberer, Lukas Mach, Friedrich Altmann, Josef Glößl, Herta Steinkellner
Veranstaltung: 5th International Symposium on Glycosyltransferases GlycoT 2006
Jahr: 2006 - GLYCO-PROTEOMICS OF YELLOW JACKET VENOM ALLERGENS
Autoren: Kolarich D, Loos A, Léonard R, Mach L, Hemmer W and Altmann F
Veranstaltung: 7TH SIENA MEETING FROM GENOME TO PROTEOME 2006 - BACK TO THE FUTURE
Jahr: 2005 - Expression of human M6P/IGF2R inhibits in vitro invasion of receptor-deficient SCC-VII murine squamous carcinoma cells
Autoren: Probst, O., Mach, L.
Veranstaltung: 1st Vienna Meeting on Tumor Invasion and Metastasis 2005
Jahr: 2005 - In vitro invasion of M6P/IGF2R-deficient squamous carcinoma cells is dependent on lysosomal cysteine proteinases and inhibited by ectopic expression of the receptor.
Autoren: Probst, O., Mach, L.
Veranstaltung: Life Sciences 2005, Joint Annual Meeting of ÖGBM, ÖGGGT, ÖGBT and ANGT
Jahr: 2005 - Expression of human M6P/IGF2R inhibits in vitro invasion of receptor-deficient SCC-VII murine squamous carcinoma cells.
Autoren: Probst, O., Mach, L.
Veranstaltung: 1st Vienna Meeting on Tumor Invasion and Metastasis 2005
Jahr: 2005 - In vitro invasion of M6P/IGF2R-deficient squamous carcinoma cells is dependent on lysosomal cysteine proteinases and inhibited by ectopic expression of the receptor.
Autoren: Probst, O., Mach, L.
Veranstaltung: 4th General Meeting of the International Proteolysis Society 2005
Jahr: 2004 - Modulation of the N-glycosylation pathway in plants
Autoren: Richard Strasser, Friedrich Altmann, Josef Glößl, Lukas Mach, Herta Steinkellner
Veranstaltung: 4th International Symposium on Glycosyltransferases 2011
Jahr: 2004 - Modulation of the N-glycosylation pathway in plants.
Autoren: Strasser,R., Altmann,F., Glößl,J., Mach,L., Herta Steinkellner
Veranstaltung: 4th International Symposium on Glycosyltransferases 2011
Jahr: 2002 - Proteolytic maturation in lysosomes: lysosomal cysteine proteinases as effectors and substrates
Autoren: Mach, L.
Veranstaltung: 3rd international conference on cysteine proteinases and their inhibitors 2002
Jahr: 2002 - The role of beta1,2-xylosyltransferase in the biosynthesis of plant glycoprotein N-glycans
Autoren: Strasser, R., Bencur, P., Dirnberger, D., Mucha, J., Glössl, J., Steinkellner, H., Mach, L.
Veranstaltung: 3rd International Symposium on Glycosyltransferases 2002 GlycoT2002
The role of proteolytic systems in liver cancer.
Autoren: Ng, K.M., Yeoh, G.C., Mach, L.
Novel lysosomal cysteine proteinases are involved in the proteolytic processing of cathepsins B, D and L.
Autoren: Mach, L., Gannon, A., Roth, W., Peters, C.
Novel lysosomal proteinases are involved in the proteolytic processing of cathepsins B, D and L.
Autoren: Mach, L., Gannon, A., Roth, W., Peters, C.
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