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Danube Allergy Research Cluster – Towards the cure of allergy

Project Leader
Lauter Kathrin, BOKU Project Leader
Duration:
01.10.2020-30.09.2023
Programme:
Großprojekte
Type of Research
Applied Research
Staff
BOKU Research Units
Institute of Bioanalytics and Agro-Metabolomics
Institute of Plant Breeding
Subproject(s):
Development of hypoallergenic plants (Danube ARC - P4)
Funded by
Amt der Niederösterreichischen Landesregierung, Landhausplatz 1, A-3109 St. Pölten, Austria
Abstract
IgE-associated allergy affects more than 30% of the population and hence is the most common immunologically mediated hypersensitivity disease. The hallmark of allergy is the formation of IgE antibodies against per se innocuous antigens (i.e., allergens) in allergic patients. IgE-allergen immune complexes trigger immediate symptoms of allergic inflammation. The unique feature of this research program is the focus on the molecular characterization of the disease-causing allergens. Clinically relevant allergens will be used to study the mechanisms of allergy in patients, to establish tools for molecular diagnosis and for the investigation of the evolution of allergy in early childhood, to investigate avoidance and vaccination strategies for personalized treatment in the sense of precision medicine and most importantly, to develop allergen-specific prevention strategies such as man-made-reduction of allergen exposure, prophylactic vaccination strategies, and preventive tolerance induction using novel vectors, adjuvants, oral tolerance induction and cell-based strategies.
The “Danube Allergy Research Cluster (Danube-ARC)” is an Allergy Research program consisting of 16 research projects. Scientists from the Medical University of Vienna are teaming up with researchers from the country of Lower Austria, i.e. the Austrian Intitute of Technology (AIT, Tulln), the BOKU Departments of Agrobiotechnology (IFA-Tulln) and Crop Sciences (DNW, Tulln) and the Karl Landsteiner University of Health Sciences (KL, Krems, St.Pölten, Tulln).
Keywords
General chemistry; Allergology; Plant breeding; Food testing; Food biotechnology;
allergy; immunoanalytical testsystems; food allergens; plant breeding;
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