CDL for Biotechnology of Skin Aging
Abstract
The functional decline of cells, organs and tissues during aging is one of the major challenges that our societies are facing today, as these impairments are the substrate on which age associated diseases are growing. The skin is the organ most exposed to agents that accelerate the aging process and the consequential loss of tissue functionality. Such a loss of skin functionality leads to increase in various age-associated skin diseases. In addition, the skin is considered a “representative” organ, whose appearance is impacting on the perception of others and ourselves. Thus age-related changes also result in cosmetic concerns that can deteriorate our social, behavioural, and psychological well-being at old age. Cellular senescence is among the reasons for functional losses of the skin during aging like the decline in its barrier function and regeneration capacity. Up to 25% of cells in the skin of elderly are estimated to become senescent. Since senescent cells lose their functionalities in vivo they are under the severe suspicion to contribute to the development of age-associated diseases and a pro-inflammatory environment. It is of interest in this context, that the removal of senescent cells in vivo delays the onset of age-associated diseases. Therefore, the long term aim of this CD laboratory on the “Biotechnology of Skin Aging” is to analyse how senescent cells in the skin might contribute to the loss of skin functionality and how plant extracts via modulation of senescence itself, miRNAs and modulation of lipid oxidation might counteract this loss. These studies will mainly be performed in human primary skin cell cultures and will be extended to human organotypic cultures resembling skin. While such skin equivalents are already on the market, no skin equivalents mimicking “aged” skin are yet available. Therefore, this CD lab will contribute to (i) a deeper understanding of how skin cell senescence impacts on functional loss of skin, (ii) establish novel plant extracts as modulators of skin cell and ECM senescence and (iii) establish novel, marketable skin equivalents as model systems for cosmetic, pharmaceutical and chemical industries.
keywords Skin aging miRNA SNEV senescence
Publikationen
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.
Autoren: Schosserer, M; Minois, N; Angerer, TB; Amring, M; Dellago, H; Harreither, E; Calle-Perez, A; Pircher, A; Gerstl, MP; Pfeifenberger, S; Brandl, C; Sonntagbauer, M; Kriegner, A; Linder, A; Weinhäusel, A; Mohr, T; Steiger, M; Mattanovich, D; Rinnerthaler, M; Karl, T; Sharma, S; Entian, KD; Kos, M; Breitenbach, M; Wilson, IB; Polacek, N; Grillari-Voglauer, R; Breitenbach-Koller, L; Grillari, J; Jahr: 2015
Journal articles
[Principles of biological aging].
Autoren: Schosserer, M; Grubeck-Loebenstein, B; Grillari, J; Jahr: 2015
Journal articles
More than 50 Years of Cellular Senescence: From In Vitro Model to Potential Drug Target?
Autoren: Schosserer, M; Grillari, J Jahr: 2014
Journal articles
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
Autoren: Garschall, K; Dellago, H; Gáliková, M; Schosserer, M; Flatt, T; Grillari, J Jahr: 2017
Journal articles
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
Autoren: Cardoso, AL; Fernandes, A; Aguilar-Pimentel, JA; de Angelis, MH; Guedes, JR; Brito, MA; Ortolano, S; Pani, G; Athanasopoulou, S; Gonos, ES; Schosserer, M; Grillari, J; Peterson, P; Tuna, BG; Dogan, S; Meyer, A; van Os, R; Trendelenburg, AU; Jahr: 2018
Journal articles
The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition
Autoren: Hager, S; Korbula, K; Bielec, B; Grusch, M; Pirker, C; Schosserer, M; Liendl, L; Lang, M; Grillari, J; Nowikovsky, K; Pape, VFS; Mohr, T; Szakács, G; Keppler, BK; Berger, W; Kowol, CR; Heffeter, P; Jahr: 2018
Journal articles
Inhibition of profibrotic microRNA-21 affects platelets and their releasate.
Autoren: Barwari, T; Eminaga, S; Mayr, U; Lu, R; Armstrong, PC; Chan, MV; Sahraei, M; Fernández-Fuertes, M; Moreau, T; Barallobre-Barreiro, J; Lynch, M; Yin, X; Schulte, C; Baig, F; Pechlaner, R; Langley, SR; Zampetaki, A; Santer, P; Weger, M; Plasenzotti, R; Schosserer, M; Grillari, J; Kiechl, S; Willeit, J; Shah, AM; Ghevaert, C; Warner, TD; Fernández-Hernando, C; Suárez, Y; Mayr, M; Jahr: 2018
Journal articles
Raman fingerprints as promising markers of cellular senescence and aging.
Autoren: Liendl, L; Grillari, J; Schosserer, M; Jahr: 2020
Journal articles
Specialized ribosomes in human dermal fibroblast senescence
Autoren: Nagelreiter, F; Yang, G; Heissenberger, C; Gonskikh, Y; Polacek, N; Grillari, J; Kos, M; Schosserer, M Jahr: 2019
Journal articles
Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents - Implications for oxidative UV damage.
Autoren: Kremslehner, C; Miller, A; Nica, R; Nagelreiter, IM; Narzt, MS; Golabi, B; Vorstandlechner, V; Mildner, M; Lachner, J; Tschachler, E; Ferrara, F; Klavins, K; Schosserer, M; Grillari, J; Haschemi, A; Gruber, F; Jahr: 2020
Journal articles
Project staff
Johannes Grillari
Assoc. Prof. Dr. Johannes Grillari
johannes.grillari@boku.ac.at
Tel: +43 1 47654-79067
BOKU Project Leader
01.07.2013 - 31.12.2020
Lucia Terlecki-Zaniewicz
Dipl.-Ing. Dr.nat.techn. Lucia Terlecki-Zaniewicz Bakk.techn.
Project Staff
01.07.2013 - 31.12.2020
BOKU partners
External partners
CHANEL Parfums Beauté_x000D_ RCS Neuilly sur Seine (92)
none
partner
University of Vienna, Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases
none
partner