Barbara Korbei
Priv.Doz. Mag. Dr. Barbara Korbei
Institute of Molecular Plant Biology
Location Muthgasse 18, 1190 Wien
Email barbara.korbei@boku.ac.at
Tel: +43 1 47654-94230
Research Focus
Due to accelerating climate change and the resulting rapid increase in extreme environmental conditions, the question of how plants can flexibly adapt to their constantly changing environment is a highly topical area of research. Plants, being sessile organisms, have evolved a plethora of mechanisms to be able to respond quickly and accurately to their surroundings. The plasma membrane serves as boundary between the inside and the outside of the cell and is densely packed with proteins that are responsible for sensing and transmitting stimuli. Plants thus have to be able to rapidly and accurately adjust not only the localization but also the amount of their plasma membrane proteins. This is organized by endosomal trafficking, which transports membrane proteins to and from their site of action. Here, the post-translational modification of plasma membrane proteins with the small protein ubiquitin is key in signaling their removal from the plasma membrane by endocytosis and further degradation in the vacuole. To understand the significance and the variety of roles played by this reversible modification, the function of ubiquitin receptors, which translate the ubiquitin signature into a cellular response, needs to be elucidated. In this lab we try to unravel the function of the TOM1-like (TOL) protein family in the recognition and in initiating sorting to the vacuole of ubiquitinated plasma membrane proteins destined for degradation. The TOL proteins function in plants as multivalent ubiquitin receptors, governing ubiquitinated cargo delivery to the vacuole via the conserved Endosomal Sorting Complex Required for Transport (ESCRT) pathway.
Career
- 2022 Institute head IMPB
- 2022 - 2024 Vice Head of Department (DAGZ)
- 2020 venia docendi "molecular cell biology"
- 2018 Principal Investigator at the Department of Applied Genetics and Cell Biology
- 2015 - 2017 Elise Richter position
- 2010 - 2014 Hertha Firnberg position
Awards
- Year: 2014 Awards: BOKU Best Paper Award des Jubiläumsfonds der Stadt Wien
Projects
0 Projects found.
Publications
Knowledge Transfer to Society
Media
Presentations
Year: 2022 - TOL proteins-ubiquitin receptors in early endocytic trafficking (Vortrag)
Autoren: Barbara Korbei
Event: International Conference on Plant Proteostasis
Year: 2019 - The role of TOL proteins, ubiquitin receptors of the endosomal degradation pathway during abiotic stress response (Poster)
Autoren: Schwihla M., Moulinier-Anzola J. and Korbei B.
Event: 22nd Meeting of the European Network for Plant Endomembrane Research
Period: 03.09.2019 - 06.09.2019 | Location: Valencia, Spain
Year: 2019 - Function and regulation of TOLs: ubiquitin receptors in the endosomal system of plants (Poster)
Autoren: Moulinier-Anzola J., De-Araújo, L., Schwihla M., Artner C., Jörg L and Korbei B.
Event: 11th Tri-National Arabidopsis Meeting TNAM 2019
Period: 10.04.2019 - 12.04.2019 | Location: Zürich, Switzerland
Year: 2019 - Function and regulation of TOLs: ubiquitin receptors in the endosomal system. (Vortrag)
Autoren: Barbara Korbei
Event: International Conference on Plant Proteostasis University of Freiburg
Period: 10.09.2019 - 13.09.2019 | Location: Freiburg im Breisgau, Germany
Year: 2019 - Wissenschaftstag für Volksschulkinder (Vortrag)
Autoren: Moulinier-Anzola J., Lucyshyn D., Feraru E., Strauss-Goller S., Schwihla M., Dünser K. and Korbei B.
Event: Kinderuni 2019
Period: 17.06.2019 - 18.06.2019 | Location: Vienna, Austria
Year: 2018 - Function and regulation of the ubiquitin binding TOL proteins and their impact on plasma membrane protein downregulation (Poster)
Autoren: De-Araújo L., Moulinier-Anzola J., Schwihla M., Artner C., Jörg L., Podgorschek E. and Korbei B.
Event: 21st Meeting of the European Network for Plant Endomembrane Research ENPER 2018
Period: 04.09.2018 - 07.09.2018 | Location: Vienna, Austria
Year: 2017 - Ubiquitin binding and conjugation is important for the function and localization of th e TOLs (Poster)
Autoren: Lucinda De-Araújo, Jeanette Moulinier-Anzola, Lisa Jörg, Christina Artner and Barbara Korbe
Event: European Network for Plant Endomembrane Research
Period: 12.09.2017 - 15.09.2017 | Location: Prague, Czech Republic | Location: Bordeaux, France | Location: Bordeaux, France
Year: 2017 - Ubiquitin binding and conjugation is important for the function and localisation of TOL proteins (Vortrag)
Autoren: Barbara Korbei
Event: From Proteome to Phenotype SEB 2017 - role of post-translational modifications
Period: 11.12.2017 - 13.12.2017 | Location: Edinburgh, Scotland, UK | Location: Edinburgh, Scotland, UK
Year: 2015 - Wiener Töchtertag (Vortrag)
Autoren: Barbara Korbei
Event: http://www.toechtertag.at/
Period: 01.04.2015 | Location: Vienna, Austria
Year: 2015 - Structure-Function Analysis of conserved ubiquitin binding domains in TOL proteins. (Poster)
Autoren: Lucinda De-Araujo, Christina Artner, Jeanette Moulinier-Anzola and Barbara Korbei
Event: EMBO Conference 2015 - Signalling in plant development
Period: 20.09.2015 - 24.09.2015 | Location: Brno, Czech Republic
Year: 2014 - Wissenschaftstag für Volksschulkinder (Vortrag)
Autoren: Barbara Korbei, Christian Luschnig
Event: Wissenschaftstag für Volksschulkinder, Kinderuni 2014
Period: 02.05.2014 | Location: Vienna, Austria
Year: 2012 - The Importance of Ubiquitin binding for a novel Group of endosomal trafficking Proteins in Arabidopsis thaliana (Poster)
Autoren: Lucinda Alculete Lopes de Araujo Feitio, Jeanette Moulinier-Anzola, Christian Luschnig, Barbara Korbei
Event: 23th International Conference on Arabidopsis Research ICAR 2012
Period: 03.07.2012 - 07.07.2012 | Location: Vienna, Austria
Year: 2012 - Elucidating the role of VHA-GAT domain proteins in endosomal vesicular transport in Arabidopsis thaliana (Poster)
Autoren: Barbara Korbei, Christian Luschinig
Event: 8th Tri-National Arabidopsis Meeting TNAM 2012
Period: 12.09.2012 - 15.09.2012 | Location: Lausanne, Switzerland