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Gewählte Master / Diploma Thesis:

Eva Maria Dorninger (1996): Etablierung der Kapillarelektrophrese in der Qualitätskontrolle rekombinanter Proteine und Antikörper.
Master / Diploma Thesis, BOKU-Universität für Bodenkultur. UB BOKU obvsg

Data Source: ZID Abstracts
In this work various techniques of capillary electrophoresis (capillary zone electrophoresis, capillary isoelectric focusing) were eveluated to its suitability in quality control of recombinant proteins and antibodies. CZE was calibrated for quantification of recombinant human superoxide dismutase and the human monoclonal antibody 3D6 (anti-HIV). In another application CZE was applied to analyse samples from an accelerated stability test of an alkaline antibody. In isoelectric focusing good separation was obtained with the model proteins Myoglobine and beta-Lactoglobuline A under neutral and acidic conditions, but not under alkaline.

Beurteilende(r): Bayer Karl

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