Modulation of the N-glycosylation pathway in plants for the productionof pharmaceutically relevant glycoproteins
Abstract
This project aims at the generation of plant lines for the production of therapeutically relevant glycoproteins. To this end the glycosylation capacity of plants shall be modified in a way that glycoproteins on one hand lack the plant-typical immunogenic N-glycans and on the other hand contain mammalian-like features, most noteworthy sialic acid. As a model we will use A. thaliana plants.
Publikationen
Molecular cloning and heterologous expression of beta1,2-xylosyltransferase and core alpha1,3-fucosyltransferase from maize.
Autoren: Bondili, JS; Castilho, A; Mach, L; Glössl, J; Steinkellner, H; Altmann, F; Strasser, R Jahr: 2006
Journal articles
Project staff
Herta Steinkellner
Ao.Univ.Prof. Mag.rer.nat. Dr.nat.techn. Herta Steinkellner
herta.steinkellner@boku.ac.at
Tel: +43 1 47654-94370
Project Leader
02.02.2004 - 30.09.2008
Friedrich Altmann
Univ.Prof. Dipl.-Ing. Dr.nat.techn. Friedrich Altmann
friedrich.altmann@boku.ac.at
Tel: +43 1 47654-77262
Sub Projectleader
02.02.2004 - 30.09.2008
Renate Kunert
Univ.Prof. Dipl.-Ing. Dr.nat.techn. Renate Kunert
renate.kunert@boku.ac.at
Tel: +43 1 47654-79852
Sub Projectleader
02.02.2004 - 30.09.2008
Alexandra Machado Ferreira Castilho
Dr. Alexandra Machado Ferreira Castilho
alexandra.castilho@boku.ac.at
Tel: +43 1 47654-94353
Project Staff
02.02.2004 - 30.09.2008
Richard Strasser
Assoc. Prof. Dr. Richard Strasser
richard.strasser@boku.ac.at
Tel: +43 1 47654-94345
Project Staff
02.02.2004 - 30.09.2008